New weight loss may help treat poisoning

“Occasionally, if you look right, you can show the light in the most strange place.” -Robert Hunter, thank you Dead, “Scarlet Begonia”

Sometimes new effective treatments are almost accidentally discovered. This occurred on a new generation of hepatitis C -type drugs with a much higher treatment rate, a smaller serious side effect, and a smaller treatment course than the treatment protocol that had been replaced for 10 years.

At that time, pharmaceutical companies were not studying for better HEP C treatment, but HIV treatment. Their clinical trials revealed that the HIV status of the research participants remained the same, but it seemed that hepatitis C could be resolved among those infected with the virus. This unintended result has revolutionized how HEP C is handled.

Similar processes may be in progress in the potential development of new effective drugs. Poisoning process. Research recently released in the journal Poisoning Opioid and/or patients found alcohol If you use a disability (OUD, AUD) taking an ozen pick or a similar medicine to treat diabetes and other weight -related status, people who do not take such drugs are more than those who have OUD or AUD. , The percentage of opioid overdose and alcohol poisoning has dramatically reduced.(1)

Ozempic is one of several drugs called glucagon-like peptide-1 receptor agonist or GLP-1 RA, and is prescribed to treat diabetes, obesity, and other weight-related conditions. The GLP-1 Agonist and glucose-dependent Insulinotropic polypeptide (GIP) agonists include the category of weight-related status include Sempgrutide (brand name Ozempic, Wegovy) and Tilzepachid.

Most studies to treat substance disorders using these drugs consisted of animal research and small clinical trials. In contrast, this large-scale human research examines the medical records of 503,747 people who have a history of opioid usage disorder, and the percentage of 8,103 people with GLP-1 RA or GIP prescription is 40 % lower. I understand that. Opioido overdose compared to those who did not have a prescription for these drugs. In the same study, 817,309 people with alcohol-use disorder are also considered, and 5,621 people who had a GLP-1 RA or GIP prescription have an alcohol poisoning rate compared to those who did not have a prescription. I found that it was 50 % lower. 。 These protection effects were consistent between various subgroups, including patients. Associate Type 2 diabetes and obesity. Importantly, these results seem to reflect the results of recent research research.(2) (3)

How does such medicine work?

These drugs work by imitating GLP-1 hormone It is generated according to eating, adjusting the weight, and interchangeable with the medium -bone system in the brain, reducing food craving and the whole. appetiteEnhance the satisfaction after eating.(4) Medium -bone blood Dopamine The route is A Nerve circuit It plays an important role in reward, motivationAnd joy. As a result, brain processes that control the addictive experience/behavior, including the use of chronic substances, are duplicated. This duplication suggests that GLP-1 RAS and similar drugs may change the reward response route associated with substances.(5)

However, the exact action mechanism related to how these drugs work is a theme of several discussions. One belief is that they are not more comfortable and not attractive to food and habitual substances. The other is that they have less craving and urge for people to encourage thirst because they are suppressing their desires. Another idea is to change the body setting point for these drugs. It is time to stop eating and using the food and material usage that you feel enough.

An anecdoons, taking these drugs for diabetes or taking them to lose weight are generally thirsty for more intense food after having a much less meal than before. He explains that he is satisfied, and feels “satisfied.” In addition, there are frequent reports among these pharmaceutical people, which provide the use of problematic substances, a decrease in drug craving and a decrease in drug -related rewards, including a sense of joy.

In its own, this new study does not demonstrate that Ozen picks and similar drugs are useful for the treatment of addiction. However, the possibility is clear, and if these discoveries are endured and the initial data from more strict clinical trials is promising, drugs may be as large as obese. Furthermore, by understanding how they work, it may dramatically change how to poisoning and being treated.

Copyright 2025, Mager, MSW.